Details of the Drug

General Information of Drug (ID: DM3W15N)

Drug Name

Calcium carbimide

Synonyms

Nitrolime; Alzodef; Aero cyanamid granular; USAF CY-2; Aero cyanamid special grade; Nitrolim; Cyanamid; Calcium cyanamid; Lime Nitroget; Cyanamid granular; NCI-C02937; CY-L 500; Cyanamid special grade; UN 1403, Nitrolime; WLN: CA NCN; NSC7078; NSC-7078

Indication

Disease Entry	ICD 11	Status	REF
Alcohol dependence	6C40.2	Approved	[1]

Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

#Ro5 Violations (Lipinski):
0

Molecular Weight

80.1

Topological Polar Surface Area

Not Available

Rotatable Bond Count

Hydrogen Bond Donor Count

Hydrogen Bond Acceptor Count

ADMET Property

Absorption Cmax: The maximum plasma concentration (Cmax) of drug is 158 mcg/L [2]
Absorption Tmax: The time to maximum plasma concentration (Tmax) is 6 h [2]
Bioavailability: The bioavailability of drug is 45% [2]
Clearance: The total plasma clearance of drug is 0.0123-0.0190 L/min/kg [3]
Elimination: The rate of elimination of ethanol when calcium carbimide is administered tends to be around 5% slower than the one presented in patients without any treatment [4]
Half-life: The concentration or amount of drug in body reduced by one-half in 92.4 minutes [5]
Vd: The volume of distribution (Vd) of drug is 0.64 L/kg [6]

Chemical Identifiers

Formula: CCaN2
IUPAC Name: calcium;azanidylidenemethylideneazanide
Canonical SMILES: C(=[N-])=[N-].[Ca+2]
InChI: InChI=1S/CN2.Ca/c2-1-3;/q-2;+2
InChIKey: MYFXBBAEXORJNB-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 56955933
ChEBI ID: CHEBI:64301
CAS Number: 156-62-7
DrugBank ID: DB09116
TTD ID: D0A9KF
INTEDE ID: DR0261

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Acetaldehyde dehydrogenase (ALDH)	TTCTAOJ	AL1A1_HUMAN; ALDH2_HUMAN; AL1B1_HUMAN	Inhibitor	[7]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Catalase (CAT)_{Main DME}	DE1XPGH	CATA_HUMAN	Substrate	[8]

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Molecular Interaction Atlas (MIA)

MIA Detail

Jump to Detail Molecular Interaction Atlas of This Drug

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Patnaik A, Rosen LS, Tolaney SM, Tolcher AW, Goldman JW, Gandhi L, Papadopoulos KP, Beeram M, Rasco DW, Hilton JF, Nasir A, Beckmann RP, Schade AE, Fulford AD, Nguyen TS, Martinez R, Kulanthaivel P, Li LQ, Frenzel M, Cronier DM, Chan EM, Flaherty KT, Wen PY, Shapiro GI: Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors. Cancer Discov. 2016 Jul;6(7):740-53. doi: 10.1158/2159-8290.CD-16-0095. Epub 2016 May 23.
3	Colom H, Prunonosa J, Peraire C, Domenech J, Azcona O, Torrent J, Obach R: Absolute bioavailability and absorption profile of cyanamide in man. J Pharmacokinet Biopharm. 1999 Aug;27(4):421-36.
4	Jones AW, Neiman J, Hillbom M: Elimination kinetics of ethanol and acetaldehyde in healthy men during the calcium carbimide-alcohol flush reaction. Alcohol Alcohol Suppl. 1987;1:213-7.
5	Encyclopedia
6	Jones AW, Neiman J, Hillbom M: Concentration-time profiles of ethanol and acetaldehyde in human volunteers treated with the alcohol-sensitizing drug, calcium carbimide. Br J Clin Pharmacol. 1988 Feb;25(2):213-21.
7	Disulfiram and calcium carbimide. Mode of action, adverse effects and clinical use. Tidsskr Nor Laegeforen. 1990 Apr 10;110(10):1224-8.
8	Vasiliou V. and Petersen D. (2010). Comprehensive toxicology (2nd ed.). Elsevier.
9	Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes. Blood. 1989 Jan;73(1):334-9.